Are Dopamine Receptors Affected By Mold?

Are Dopamine Receptors Affected By Mold?

What Is The Link Between Mold and Parkinson’s Disease?

What Is The Link Between Mold and Parkinson's Disease?
What Is The Link Between Mold and Parkinson’s Disease?

One of the goals of Valor Mold is to help consumers in our service area of Washington DC gain awareness of mold and indoor air quality issues. To date, we have published 20 articles on our blog.

One of the most contentious issues is the link that mold has to ill health.

According to the CEO of Wonder Makers, Michael Pinto, there are two drastic views of mold’s impact on health.

  1. There are “mold minimizers“, ie. individuals that play down the impact that mold has on health.
  2. There are “fungiphobics“, ie. individuals that believe that mold is a harmful environmental toxin that can cause many health concerns.

Unfortunately, this is is not a black or white issue. The problem with mold is that it impacts the health of everyone differently. This is likely the reason that some people are more adversely impacted than others.

One of the goals of the Valor Mold team is to provide our readers with articles that inform and educate. As stated by Herbert Spencer:

The great aim of education is not knowledge but action.

In other words, our mission is to provide you with knowledge so that you can make informed decisions and choices.

There is a growing body of research on the impact that mold has on health, particularly for individuals that are sensitized to mold.

Previously, we wrote about the impact that mold has on asthma and sinusitis. This article explores the impact that mold has on dopamine receptors which some researchers believe is impacted by mold possibly causing Parkinson’s Disease.

Important Facts And Stats On Parkinson’s Disease!

Dopamine is a neurotransmitter that helps control the brain’s reward and pleasure centers.

Dopamine also helps regulate movement and emotional responses, and it enables us not only to see rewards, but to take action to move toward them.

Parkinson’s disease (PD), discovered by Dr. James Parkinson in 1817, is a degenerative disorder of the central nervous system caused by the death of dopamine-generating cells in a region of the midbrain, substantia nigra.

  1. Currently, there is no cure for PD.
  2. PD is treated with medications, exercise programs, speech therapy. Deep brain stimulation is another treatment option that has worked on some PD patients.
  3. The cause of PD is not known. There are many theories, including environmental factors such as pesticide exposure from two pesticides, paraquat and rotenone, commonly used by farmers affecting populations living in rural communities. The other main thrust of research focuses on genetic factors because 15% of PD patients have first-degree relatives that also suffered from PD.
  4. As many as one million Americans live with Parkinson’s disease, which is more than the combined number of people diagnosed with multiple sclerosis, muscular dystrophy and Lou Gehrig’s disease.
  5. Approximately 60,000 Americans are diagnosed with Parkinson’s disease each year, and this number does not reflect the thousands of cases that go undetected.
  6. An estimated seven to 10 million people worldwide are living with Parkinson’s disease.
  7. Incidence of Parkinson’s increases with age, but an estimated four percent of people with PD are diagnosed before the age of 50.
  8. Men are one and a half times more likely to have Parkinson’s than women.
  9. The combined direct and indirect cost of Parkinson’s, including treatment, social security payments and lost income from inability to work, is estimated to be nearly $25 billion per year in the United States alone.
  10. Medication costs for an individual person with PD average $2,500 a year, and therapeutic surgery can cost up to $100,000 dollars per patient.

What Impact, If Any, Do Microbial Volatile Organic Compounds (MVOCs) Have On Dopamine Receptors?

What Impact, If Any, Do Microbial Volatile Organic Compounds (MVOCs) Have On Dopamine Receptors?
What Impact, If Any, Do Microbial Volatile Organic Compounds (MVOCs) Have On Dopamine Receptors?

According to EMLab, MVOCS are:

“composed of low molecular weight alcohols, aldehydes, amines, ketones, terpenes, aromatic and chlorinated hydrocarbons, and sulfur-based compounds, all of which are variations of carbon-based molecules. MVOC’s have a very low odor threshold, thus, making them easily detectable by smell. They often have strong odors and are responsible for the odious smells (“old cheese”, “dirty socks” or “locker room”) associated with mold and bacterial growth….In the indoor environment, exposure to fungal MVOC’s has been blamed for headaches, nasal irritation, dizziness, fatigue, and nausea.”

One of the reasons that people get sick from molds like Aspergillus, Chaetomium, and Penicillium, is they release MVOCs.

According to researchers from Rutgers and Emory Universities–Arati A. Inamdara, Muhammad M. Hossain, Alison I. Bernstein, Gary W. Miller, Jason R. Richardson, and Joan Wennstrom Bennett–MVOCs can have an impact on dopamine production in the brain.

In their research paper, published in the Proceedings of the National Academy of Sciences: Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration, researchers hypothesized that MVOCs have the potential to damage dopamine and cause PD symptoms:

“Parkinson’s has been linked to exposure to environmental toxins, but the toxins were man-made chemicals. In this paper, we show that biologic compounds have the potential to damage dopamine and cause Parkinson’s symptoms.”

Lead researcher, Joan Wennstrom Bennett, who was a previous critic of Sick Building Syndrome, hypothesized that MVOCs made her sick because she experienced the health impact that mold can have after her home became infested with mold during Hurricane Katrina. In her words:

“I felt horrible – headaches, dizziness, nausea. I knew something about ‘sick building syndrome’ but until then I didn’t believe in it. I didn’t think it would be possible to breathe in enough mold spores to get sick.”

To prove her hypothesis, the team of researchers studied the effect that the MVOC, 1-octen-3-ol, also known as mushroom alcohol, had on the movement of fruit flies.

The researchers discovered that mushroom alcohol causes two genes involved in the packaging and transport of dopamine to malfunction causing the neurons to degenerate.

Not surprisingly, the fruit fruit flies’ movement was impacted.

The researchers proved that MVOCs impact dopamine which is one of the key causes of PD.

This is an important discovery because it creates further questions about the current hypothesis that the main cause of PD is pesticides and genetics. As stated by Inamdar:

“Our work suggests that 1-octen-3-ol might also be connected to the disease, particularly for people with a genetic susceptibility to it. We’ve given the epidemiologists some new avenues to explore.”

Are There Any Similarities Between Chronic Inflammatory Response Syndrome and PD?

Are There Any Similarities Between Chronic Inflammatory Response Syndrome and PD?
Are There Any Similarities Between Chronic Inflammatory Response Syndrome and PD?

Many of the symptoms of Chronic Inflammatory Response Syndrome (CIRS) include the following:

  1. Memory issues
  2. Concentration issues
  3. Confusion
  4. Disorientation
  5. Mood swings
  6. Vertigo
  7. Tremors

Similarly, symptoms of Parkinson’s Disease include the following:

  1. Tremors
  2. Slowness in movements
  3. Balance problems
  4. Muscle stiffness
  5. Fatigue
  6. Difficulties speaking and writing
  7. Sleep disorders
  8. Loss of smell
  9. Depression
  10. Cognitive changes

Considering the similarities in symptoms between PD and CIRS, and the fact that there is now some research evidence proving that MVOCs, a by-product of mold growth, can impact dopamine function in the brain, this raises a critical question: What percentage of PD patients are sick because of mold exposure? Hopefully, future research will provide more answers to this question.

Got Mold Questions?

Valor Mold is here to help! If you suspect that mold is making you sick, call us, 571-210-2040 or send us an e-mail. We look forward to serving you! 🙂

Parkinson’s Disease Summary!

Important Facts And Stats On Parkinson's Disease
Parkinson’s Disease Summary!

1 Comment

  • In your article, you stated that If mold is not properly contained and cleaned properly, it can become airborne and contaminate even larger areas of the property. My brother called me at work this morning because he said he could smell a really weird smell in his basement. I wonder what types of chemicals most services use to get rid of mold.

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